I am a senior scientist working with food safety at the Department of Toxicology and Risk Assessment at the Norwegian Institute of Public Health.
My research is focusing on the study of potentially harmful chemicals in foods and consumer products. I started many years ago with experiments in cell cultures and continued with experiments in experimental animals. Of special interest is the importance of metabolism in the activation of contaminants into reactive metabolites, where human activation might be more pronounced than in rodents. In my previous work I used transgenic animals with human enzymes to mimic the human activation, to study if humans can be more sensitive to the contaminants that rodents. Recently I have been involved in a large EU project called EuroMix, where I have been responsible for establising a human biomonitoring study where we will study real-life exposure to mixtures of chemicals from foods and personal care products. I have long experience with risk assessment of compounds from food, where new methods in risk assessment has been included, such as risk-benefit, benchmark dose response, weight-of-evidence approach and uncertainty evaluation in exposure and hazard characterisation.
Mosdøl A, Vist GE, Svendsen C, Dirven H, Lillegaard ITL, Mathisen GH, Husøy T. Hypotheses and evidence related to intense sweeteners and effects on appetite and body weight changes: A scoping review of reviews. PLoS One, 13, 2018
von Goetz N, Pirow R, Hart A, Bradley E, Poças F, Arcella D, Lillegard ITL, Simoneau C, van Engelen J, Husøy T, Theobald A, Leclercq C. Including non-dietary sources into an exposure assessment of the European Food Safety Authority: The challenge of multi-sector chemicals such as Bisphenol A. Regul Toxicol Pharmacol 85, 70-78, 2017
Solecki R, Kortenkamp A, Bergman Å, Chahoud I, Degen GH, Dietrich D, Greim H, Håkansson H, Hass U, Husoy T, Jacobs M, Jobling S, Mantovani A, Marx-Stoelting P, Piersma A, Ritz V, Slama R, Stahlmann R, van den Berg M, Zoeller RT, Boobis AR. Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement. Arch Toxicol 91,1001-1006, 2017
Huffman MP, Høie AH, Svendsen C, Brunborg G, Murkovic M, Glatt H, Husøy T. An in vitro study on the genotoxic effect of substituted furans in cells transfected with human metabolizing enzymes: 2,5-dimethylfuran and furfuryl alcohol. Mutagenesis 5, 597-602, 2016
Høie AH, Svendsen C, Rasmussen T, Alexander J, Husøy T. Intestinal Tumor Development in C57BL/6J-ApcMin/+ Mice Expressing Human Sulphotransferases 1A1 and 1A2 After Oral Exposure to 2,5-Dimethylfuran. Anticancer Res 36, 545-553, 2016.
In the beginning of 2015 the EU projcet “European Test and Risk Assessment Strategies for Mixtures” was funded by Horizon2020. I am the leader of workpackage 7, and in October we were interwieved by The Research Council of Norway (in Norwegian).