Welcome to Trine Husøy’s homepage

I am a senior scientist working with food safety at the Department of Toxicology and Risk Assessment at the Norwegian Institute of Public Health.

My research is focusing on the study of  potentially harmful chemicals in foods and consumer products.  I started many years ago with experiments in cell cultures and continued with experiments in experimental animals. Of special interest is the importance of metabolism  in the activation of contaminants into reactive metabolites, where human activation might be more pronounced  than in rodents. In my previous work I used transgenic animals with human enzymes  to mimic the human activation, to study if humans can be more sensitive to the contaminants that rodents. Recently I have been involved in a large EU project called EuroMix, where I have been responsible for establising a human biomonitoring study where we will study real-life exposure to mixtures of chemicals from foods and personal care products. I have long experience with risk assessment of compounds from food, where new methods in risk assessment has been included, such as risk-benefit, benchmark dose response, weight-of-evidence approach and uncertainty evaluation in exposure and hazard characterisation.

Recent highlights

Mosdøl A, Vist GE, Svendsen C, Dirven H, Lillegaard ITL, Mathisen GH, Husøy T. Hypotheses and evidence related to intense sweeteners and effects on appetite and body weight changes: A scoping review of reviews.  PLoS One, 13, 2018

von Goetz N, Pirow R, Hart A, Bradley E, Poças F, Arcella D, Lillegard ITL, Simoneau C, van Engelen J, Husøy T, Theobald A, Leclercq C.  Including non-dietary sources into an exposure assessment of the European Food Safety Authority: The challenge of multi-sector chemicals such as Bisphenol A. Regul Toxicol Pharmacol  85, 70-78, 2017

Solecki R, Kortenkamp A, Bergman Å, Chahoud I, Degen GH, Dietrich D, Greim H, Håkansson H, Hass U, Husoy T, Jacobs M, Jobling S, Mantovani A, Marx-Stoelting P, Piersma A, Ritz V, Slama R, Stahlmann R, van den Berg M, Zoeller RT, Boobis AR.  Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement. Arch Toxicol 91,1001-1006, 2017

Huffman MP, Høie AH, Svendsen C, Brunborg G, Murkovic M, Glatt H, Husøy T. An in vitro study on the genotoxic effect of substituted furans in cells transfected with human metabolizing enzymes: 2,5-dimethylfuran and furfuryl alcohol. Mutagenesis 5, 597-602, 2016

Høie AH, Svendsen C, Rasmussen T, Alexander J, Husøy TIntestinal Tumor Development in C57BL/6J-ApcMin/+ Mice Expressing Human Sulphotransferases 1A1 and 1A2 After Oral Exposure to 2,5-Dimethylfuran. Anticancer Res 36, 545-553, 2016.

In the beginning of 2015 the EU projcet “European Test and Risk Assessment Strategies for Mixtures” was funded by Horizon2020. I am the leader of workpackage 7, and in October we were interwieved by The Research Council of Norway (in Norwegian).

http://www.forskningsradet.no/no/Nyheter/Jobbet_seg_inn_i_det_beste_konsortiet/1254013001442?lang=no

 

Trine Vega