Publications the last ten years


  1. Husøy T, Knutsen HK, Cruciani V, Ølstørn HB, Mikalsen SO, Løberg EM, Alexander J. Connexin43 is overexpressed in ApcMin/+-mice adenomas and co-localises with Cox II in myofibroblasts. J. Cancer, 116, 351-358, 2005. 
  2. Husøy T, Abramsson-Zetterberg L, Ølstørn HB, Paulsen JE, Alexander J: Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes. Mutation Res, 580, 111-118, 2005. 
  3. Husøy T, Mangschou B, Fotland TØ, Kolset SO, Nøtvik Jakobsen H, Tømmerberg I, Bergsten C, Alexander J, Frost Andersen L: Reducing added sugar intake in Norway by replacing sugar sweetened beverages with beverages containing intense sweeteners – a risk benefit assessment. Food and Chemical Toxicology, 46, 3099-3105, 2008. 
  4. Husøy T, Haugen M, Murkovic M, Jöbstl D, Stølen LH, Bjellas T, Rønningborg C, Glatt H, Alexander J: Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites as biomarkers for short time exposure. Food and Chemical Toxicology, 46, 3697-3702, 2008. 
  5. Svendsen C, Alexander J, Knutsen H, Husøy T. The Min mouse on FVB background; Susceptibility to spontaneous and carcinogen-induced intestinal tumourigenesis. Anticancer Research 31, 785-788, 2011.
  6. Svendsen C, Alexander J, Paulksen JE, Knutsen HK, Hjertholm H, Brantsæter AL, Husøy T. The impact of commercial rodent diets on the induction of tumours and flat ACF in the intestine of Min mice. Laboratory animals 46, 207-214, 2012.
  7. Svendsen C, Meinl W, Glatt H, Alexander J, Knutsen H, Hjertholm H, Rasmussen T, and Husøy T. Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB Min mice expressing human sulfotransferases. Molecular Carcinogenesis 51, 984-992, 2012. 
  8. Fotland TØ, Paulsen JE, Sanner T, Alexander A, Husøy T. Risk assessment of coumarin using the bench mark dose (BMD) approach: Children in Norway which regularly eat oatmeal porridge with cinnamon are at risk for exceeding TDI for coumarin with more than twenty folds. Food and Chemical Toxicology 50, 903 -912, 2012.
  9. Høie AH, Svendsen C, Brunborg G, Glatt H, Alexander J, Meinl W, Husøy T. Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay. Environ Mol Mutagen, 56, 709-714, 2015. 
  10. Høie AH, Monien BH, Sakhi AK, Glatt H, Hjertholm H, Husøy T. Formation of DNA adducts in wild-type and transgenic mice expressing human sulfotransferases 1A1 and 1A2 after oral exposure to furfuryl alcohol. Mutagenesis 30, 643-649, 2015. 
  11. Høie AH, Monien BH, Glatt H, Hjertholm H , Husøy T. DNA adducts induced by food mutagen PhIP in a mouse model expressing human sulfotransferases 1A1 and 1A2. Toxicology Letters 248, 34–38, 2016
  12. Misiorek JO, Lähdeniemi IAK, Nyström JH, Paramonov V, Gullmets JA, Helena Saarento H, Rivero-Müller A, Husøy T, Taimen P and Toivola DT. Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway.  Carcinogenesis, accepted for publication 2016.
  13. Solecki R, Bergman Å, Boobis A, Chahoud I, Degen G, Dietrich G, Greim H, Håkansson H, Hass U, Husøy T, Jacobs M, Jobling S, Mantovani A, Marx-Stoelting P, Piersma A, Slama R, Stahlmann R, van den Berg M, Zoeller RT, and Kortenkamp A. Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement.  In press Archives Toxicology
  14. Svendsen C, Høie AH, Alexander J, Murkovic M, Husøy T. The food processing contaminant glyoxal promotes tumour growth in the multiple intestinal neoplasia (Min) mouse model.  Food and Chemical Toxicology 94, 197-202, 2016.


Monographs as main author last ten years

  1. Impact on health when sugar is replaced with intense sweeteners in soft drinks, ‘saft’ and nectar. Norwegian Scientific Committee for Food Safety. 2007 ISBN 978-82-8082-201-7
  2. Scientific Opinion on Bisphenol A: evaluation of a study investigating its neurodevelopmental toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of bisphenol A. EFSA Journal 2010; 8(9):1829
  3. Risk assessment of coumarin intake in the Norwegian population. Norwegian Scientific Committee for Food Safety. 2010 ISBN 978-82-8259-005-1
  4. Risk assessment of furan exposure in the Norwegian population. Opinion of the Panel on Food Additives, Flavourings, Processing Aids, Materials in Contact with Food and Cosmetics and the Panel on Contaminants of the Norwegian Scientific Committee for Food Safety. 2012 ISBN 978-82-8259-064-8
  5. Risk assessments of cyclamate, saccharin, neohesperidine DC, steviol glycosides and neotame from soft drinks, “saft” and nectar. Norwegian Scientific Committee for Food Safety. 2014 ISBN 978-82-8259-131-7
  6. Risk assessments of aspartame, acesulfame K, sucralose and benzoic acid from soft drinks, “saft”, nectar and flavoured water. Norwegian Scientific Committee for Food Safety. 2014 978-82-8259-151-5
  7. Scientific Opinion on the Risks to Public Health Related to the Presence of Bisphenol A (BPA) in Foodstuffs. EFSA Journal 2015;13(1):3978


Other important publications

  1. Paulsen JE, Steffensen IL, Løberg EM, Husøy T, Namork E, Alexander J: Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis in the Min/+ mouse colon. Cancer Research 61, 5010-5015, 2001. Cited 79 times
  2. Husøy T, Cruciani V, Sanner T, Mikalsen SO: Phosphorylation of connexin43 and inhibition of gap junctional communication in 12-O-tetradecanoylphorbol-13-acetate-exposed R6 fibroblasts: minor role of protein kinase CbI and m. Carcinogenesis 22, 221-231, 2001. 22 Cited 22 times
  3. Cruciani V, Husøy T, Mikalsen SO: Pharmacological evidence for system-dependent involvement of protein kinase C isoenzymes in phorbol ester-suppressed gap junctional communication. Experimental Cell Research 268, 150-161, 2001. Cited 17 times
  4. Husøy T, Cruciani V, Knutsen HK, Mikalsen SO, Ølstørn HB, Alexander J: Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerisation. Carcinogenesis, 24, 643-650, 2003. Cited 15 times
  5. Solhaug A, Refsnes M, Låg M, Schwarze PE, Husøy T, Holme JA: Polycyclic aromatic hydrocarbons induce both apoptotic as well as anti-apoptotic signals in Hepa1c1c7 cells. Carcinogenesis, 25, 809-19, 2004. Cited 91 times
  6. Husøy T, Ølstørn HB, Knutsen HK, Løberg EM, Cruciani V, Mikalsen SO, Goverud IL, Alexander J: Truncated mouse adenomatous polyposis coli reduces connexin32 level and increases matrilysin secretion from Paneth cells. European Journal of Cancer, 40, 1599-1603, 2004.
  7. Knutsen HK, Ølstørn HB, Paulsen JE, Husøy T, Goverud IL, Løberg EM, Kristiansen K, Alexander J: Overexpression of PPARb/δ and cyclin D1 in dysplastic aberrant crypt foci and in intestinal adenomas in azoxymethan-treated ApcMin/+ mice and in tumours from human FAP. Anticancer Research, 25, 3781-3789, 2005. Cited 22 times
  8. Svendsen C, Husøy T, Glatt H, Paulsen JE and Alexander J. 5-Hydroxymethylfurfural and the metabolite 5-sulfooxymethylfurfural increases adenoma and flat aberrant crypt foci number in the intestine of Min/+ mice. Anticancer Research 29, 1921-1926, 2009. Cited 18 times